Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl / 6 mice

Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection

TUMORES FILÓIDES GIGANTES (VARIANTES BENIGNA E MALIGNA): ALTERAÇÕES CLÍNICAS, TRATAMENTO CIRÚRGICO E SEGUIMENTO AMBULATORIAL – RELATOS DE CASOS

Phyloid Tumors are rare fibroepithelial tumors of the breast, representing less than 1% of all breast neoplasms, affecting women in the age group with the highest incidence between 40 and 50 years. With a variable biological behavior, the spectrum of benign presentation is confused with cellular fibroadenoma and, not the other extreme, the malignant presents similarities with other malignant neoplasms of the breast. Indicate, appear as a palpable, smooth, multinodular, firm, mobile and painless tumor, with abnormal mammographic and ultrasound findings. Tumor growth is usually rapid, with no correlation with increased risk of malignancy. The diagnosis is confirmed by histopathological evaluation. The treatment is eminently surgical, with excision with free margins and even mastectomy, a tumor-dependent extension being indicated. The presence of margins is important, since this contributes to the reduction of local recurrences, very common in this type of tumor. Adjuvant radiotherapy is controversial in the literature, but it appears to reduce recurrence without changing mortality. This article requires 02 cases of Phyloid Tumor, a benign and malignant variant, with which we aim to emphasize the importance of differential diagnosis and adequate surgical treatment, especially less postoperative morbidity.Os Tumores Filoides são tumores fibroepiteliais raros da mama, representando menos de 1% de todas as neoplasias mamárias, acometendo mulheres na faixa etária de maior incidência entre 40 e 50 anos. Com comportamento biológico variável, o espectro de apresentação benigna se confunde com o fibroadenoma celular e, no outro extremo, o maligno apresenta semelhanças com outras neoplasias malignas da mama. Geralmente, aparecem na forma de tumoração palpável, lisa, multinodular, firme, móvel e indolor, com achados mamográficos e ultrassonográficos anormais. O crescimento tumoral costuma ser rápido, sem correlação com maior risco de malignidade. O diagnóstico é confirmado por avaliação histopatológica. O tratamento é eminentemente cirúrgico, sendo indicada excisão com margens livres e, até mesmo, mastectomia, a depender da extensão tumoral. É importante a presença de margens livres, visto que isso contribui para a redução das recidivas locais, muito comuns nesse tipo de tumor. Radioterapia adjuvante é controversa na literatura, mas parece reduzir a recorrência, sem alterar a mortalidade. Esse artigo descreve 02 casos de Tumor Filoides, variante benigna e maligna, com os quais objetivamos ressaltar a importância do diagnóstico diferencial e adequado tratamento cirúrgico, visando menor morbidade pós-operatória